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isoniazid will raise the degree or effect of pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Prevent coadministration of pazopanib with powerful CYP3A4 inhibitors if possible; if have to coadminister, lessen pazopanib dose to four hundred mg/working dayMonitor Intently (one)sodium zirconium cyclosilica